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PF-04995274
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PF-04995274图片
CAS NO:1331782-27-4
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
500 mg电议
1 mL*10 mM(in DMSO)电议

产品介绍
PF-04995274 是强效,高亲和力,口服活性血清素 4 受体的部分激动剂。它是可脑渗透的,可用于与阿尔茨海默症相关的认知障碍的研究。

产品描述

PF-04995274 is an effective, high-affinity, and partial serotonin 4 receptor (5-HT4R) agonist. PF-04995274 is brain penetrant and can be used for cognitive disorders associated with Alzheimer's disease. PF-04995274 has an EC50 range of 0.26-0.47 nM for human 5-HT4A/4B/4D/4E (Ki range of 0.15-0.46 nM). It also has an EC50 range of 0.59-0.65 nM for rat 5-HT4S/4L/4E (Ki of 0.30 nM for rat 5-HT4S).

体外活性

PF-04995274 shows Ki values of 0.36 nM, 0.46 nM, 0.15 nM, 0.32 nM and 0.3nM for human 5-HT4A/4B/4D/4E and rat 5-HT4S, respectively. PF-04995274 displays EC50 values of 0.47 nM, 0.36 nM, 0.37 nM, 0.26 nM, 0.59 nM, 0.65 nM and 0.62 nM for human 5-HT4A/4B/4D/4E and rat 5-HT4S/4L/4E, respectively [3].

体内活性

PF-04995274 (3-10 mg/kg; intravenous injection; for 17 days; male 129S6/SvEv mice) treatment causes prophylactic efficacy by attenuating learned fear. It also decreasing stress-induced depressive-like behavior[1].

Cas No.

1331782-27-4

分子式

C23H32N2O6

分子量

432.51

别名

PF-04995274

储存和溶解度

DMSO:100 mg/mL (231.21 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years