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DMAPT
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
DMAPT图片
CAS NO:870677-05-7
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
1 mL电议

产品名称
Dimethylamino Parthenolide
产品介绍
DMAPT 是一种具有口服活性的NF-Κb抑制剂,是一种 Parthenolide (PTL) 的类似物,对原发性急性髓性白血病细胞的LD50值为1.7 μM。具有潜在的抗肿瘤和抗转移作用。

产品描述

DMAPT is a water-soluble analogue of Parthenolide (PTL). It is an orally active NF-κB inhibitor with an LD50 of 1.7 μM on primary acute myeloid leukemia cells.

体外活性

DMAPT treatment reduced the constitutive NF-κB binding activity and inhibited the proliferation and viability of PC-3 and DU145 cells. Treatment of PC-3 and DU145 cells with 5 and 4 μM DMAPT, respectively, increased the population doubling time of PC-3 prostate cancer cells from 23.0±5.0 h to 42.0±3.0 h, while the population doubling time of DU145 cells increased from 20.4±2.2 h By 72.5±24.8 hours.

体内活性

DMAPT (100 mg/kg, oral gavage daily for 7 days) treatment can increase the sensitivity of PC-3 tumor xenografts to X-rays. DMAPT (100 mg/kg, 42 to 300 days from birth, oral gavage three times a week) treatment can slow the normal tumor development of TRAMP mice and prolong the reachable prostate tumor time by 20%. DMAPT further reduced the lung tissue transfer area of TRAMP mice to below the water vehicle treatment group (0.10%±0.15 SD, 92% reduction, p = 0.0028)[3].

Cas No.

870677-05-7

分子式

C17H27NO3

分子量

293.4

别名

Dimethylamino Parthenolide;DMAPT

储存和溶解度

DMSO:100 mg/mL (340.83 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years