AMG8379 is a novel, potent, orally bioactive and selective antagonist of the voltage-gated sodium channel NaV1.7 with IC50s of 8.5 and 18.6 nM for hNaV1.7 and mNaV1.7,
respectively. AMG8379 potently and reversibly blocks endogenous
Tetrodotoxin (TTX)-sensitive sodium channels in dorsal root ganglia
(DRG) neurons with an IC50 of 3.1 nM.
纯度:≥98%
CAS:1642112-31-9