THP-PEG4-Pyrrolidine(N-Boc)-CH2OH is a PEG-based PROTAC linker can be used in the synthesis of PROTAC K-Ras Degrader-1[1].

PROTAC K-Ras Degrader-1 is potent?K-Ras?degrader based?PROTAC, exhibits ≥70% degradation efficacy in SW1573 cells[1].PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein.PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

2378261-80-2

C23H43NO9

477.59

THP-PEG4-Pyrrolidine(N-Boc)-CH2OH

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years