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AcLysValCit-PABC-DMAE-SW-163D
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
AcLysValCit-PABC-DMAE-SW-163D图片
CAS NO:2411007-69-5
包装与价格:
包装价格(元)
100 mg电议
500 mg电议

产品介绍

产品描述

AcLysValCit-PABC-DMAE-SW-163D is a drug-linker conjugates for ADC which consists of a natural bis-intercalator, SW-163D, conjugated via an AcLysValCitPABC-DMAE linker[1].

体外活性

SW-163D is a cyclodepsipeptide antibiotic that is isolated from Streptomyces sp. SW-163D also exhibits antitumour activity. PF06888667 is a potent, stable, and efficacious ADC that consists of the bis-intercalator, SW-163D, conjugated via an N-acetyl-lysine-valine-citrulline-p-aminobenzyl alcohol-N,N-dimethylethylenediamine (AcLysValCitPABC-DMAE) linker to an engineered variant of the anti-Her2 mAb, trastuzumab, catalyzed by transglutaminase[1].

Cas No.

2411007-69-5

分子式

C85H113N19O22S2

分子量

1817.05

别名

AcLysValCit-PABC-DMAE-SW-163D

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years