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Abacavir sulfate(ABC)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Abacavir sulfate(ABC)图片
CAS NO:188062-50-2
规格:≥98%
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议
1g电议
2g电议
10g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)335.35
FormulaC14H18N6O.1/2 H2O4S
CAS No.188062-50-2 (sulfate);
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: <1 mg/mL
Water: 36 mg/mL (107.4 mM)
Ethanol: <1 mg/mL
Other info
Chemical Name: [(1S,4R)-4-[2-amino-6-(cyclopropylamino)purin-9-yl]cyclopent-2-en-1-yl]methanol sulfuric acid
InChi Key: MBFKCGGQTYQTLR-SCYNACPDSA-N
InChi Code: InChI=1S/C14H18N6O.H2O4S/c15-14-18-12(17-9-2-3-9)11-13(19-14)20(7-16-11)10-4-1-8(5-10)6-21;1-5(2,3)4/h1,4,7-10,21H,2-3,5-6H2,(H3,15,17,18,19);(H2,1,2,3,4)/t8-,10+;/m1./s1
SMILES Code: OC[C@@H]1C=C[C@H](N2C=NC3=C(NC4CC4)N=C(N)N=C23)C1.O=S(O)(O)=O
SynonymsAbacavir Hemisulfate; ABC sulfate; 1592U89; ABC, Ziagen; Epzicom; 1592 U89; 1592 U89; 1592U-89; 1592-U89; 1592 U 89.
实验参考方法
In Vitro

In vitro activity: Abacavir sulfate (ABC) is a powerful nucleoside analog reverse transcriptase inhibitor (NRTI) used to treat HIV and AIDS. Target: NRTI Abacavir is a nucleoside reverse transcriptase inhibitor marketed since 1999 for the treatment of infection with the human immunodeficiency virus type 1 (HIV). Despite its clinical efficacy, abacavir administration has been associated with serious and sometimes fatal toxic events. Abacavir has been reported to undergo bioactivation in vitro, yielding reactive species that bind covalently to human serum albumin, but the haptenation mechanism and its significance to the toxic events induced by this anti-HIV drug have yet to be elucidated. The mechanism underlying abacavir hypersensitivity syndrome is related to the change in the HLA-B*5701 protein product.


Cell Assay: Abacavir binds with high specificity to the HLA-B*5701 protein, changing the shape and chemistry of the antigen-binding cleft. This results in a change in immunological tolerance and the subsequent activation of abacavir-specific cytotoxic T cells, which produce a systemic reaction known as abacavir hypersensitivity syndrome.

In Vivo
Animal model
Formulation & Dosage
ReferencesLancet. 2002 Mar 2;359(9308):727-32; N Engl J Med. 2008 Feb 7;358(6):568-79.