Men 10376 is a selective antagonist of tachykinin NK-2 receptor. It has a Ki of 4.4 μM for rat small intestine NK-2 receptor.

Men 10376 is a selective tachykinin NK-2 receptor (Ki: 4.4 μM). Men 10376 displays no effect on NK-3 receptor (Ki, >10 μM). It also displays low selectivity for NK-1 and NK-3 receptors (Ki, >10 μM)[1]. Men 10376 shows pA2s of 5.66 and 8.08 for NK-1 (guinea-pig ileum) and NK-2 receptors (endothelium-deprived rabbit pulmonary artery). [2].

Men 10376 (1 and 3 μmol/kg; in rats) antagonizes an enhance in bladder motility produced by the NK-2 receptor agonist [2].

135306-85-3

C57H68N12O10

1081.22

Neurokinin-2 receptor antagonist;Men 10376

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years