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BMS-538203
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
BMS-538203图片
CAS NO:543730-41-2
规格:≥98%
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
250mg电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)269.23
FormulaC12H12FNO5
CAS No.543730-41-2
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: ≥ 54 mg/mL
Water:<1 mg/mL
Ethanol:<1 mg/mL
SMILES CodeO=C(O)/C(O)=C/C(N(CC1=CC=C(F)C=C1)OC)=O
SynonymsBMS-538203; BMS538203; BMS 538203.
实验参考方法
In Vitro

In vitro activity: BMS-538203 is a novel and highly efficient HIV integrase inhibitor and antiviral agent. BMS-538203 was discovered by a hit-to-clinical candidate pathway that resulted in 50- and 2000-fold improvements in enzyme-inhibition and antiviral activity without an increase in molecular weight or change in molecular topology. The original hit, 1 (mw = 268) was optimized in a stepwise manner. Potential covalent protein-binding moieties were removed by reducing the number of the ketone groups. High enzyme inhibition activity was achieved by optimizing the aryl-portion of the molecule. Protein binding was reduced by replacing the standard amide by the corresponding methyl-hydroxamide. This eventually led to the discovery of compound 2 (BMS-538203, mw = 269) a highly efficient inhibitor and antiviral agent.

In Vivo
Animal model
Formulation & Dosage
ReferencesRU patent 2367439.