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Omecamtiv mecarbil(CK1827452)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Omecamtiv mecarbil(CK1827452)图片
CAS NO:873697-71-3
规格:≥98%
包装与价格:
包装价格(元)
2mg电议
5mg电议
25mg电议
50mg电议
100mg电议
250mg电议
500mg电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)401.43
FormulaC20H24FN5O3
CAS No.873697-71-3
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 80 mg/mL (199.3 mM)
Water: <1 mg/mL
Ethanol: 6 mg/mL (14.9 mM)
Solubility (In vivo)1% DMSO+30% polyethylene glycol+1% Tween 80: 30 mg/mL
SynonymsCK1827452; CK 1827452; CK1827452; Omecamtiv mecarbil.
实验参考方法
In Vitro

In vitro activity: In vitro, Omecamtiv mecarbil selectively activates cardiac myosin by increasing the myosin ATPase rate. In isolated cardiac myocytes, Omecamtiv mecarbil results in increase of myocyte contractility and overcomes of the myosin inhibitor BDM without increasing the calcium transient or inhibiting the PDE pathway.

In VivoOmecamtiv mecarbil significantly increases fractional shortening starting at 0.4 mM plasma concentrations in SD rats, sham animals and in rats with heart failure. In conscious dogs with myocardial infarction (MI-sHF), Omecamtiv mecarbil leads to a significant increase in wall thickening (25%), stroke volume (44%), cardiac output (22%) and left ventricular (LV) systolic ejection time (26%). In addition, Omecamtiv mecarbil also results in the decreases of some hemodynamic parameters including heart rate, mean left atrial pressure, and LV end-diastolic pressure. In conscious dogs with left ventricular hypertrophy (LVH-sHF), Omecamtiv mecarbil leads to similar and not statistically different effects on hemodynamic parameters.
Animal modelSprague Dawley rats.
Formulation & DosageDissolved in DMSO and then diluted in water; ≤1.2 mg/kg/hour; i.v. injection.
References

Circ Heart Fail. 2010 Jul;3(4):522-7.