生物活性
Brexpiprazole是一种新型的D2多巴胺部分激动剂研究产品，目前正在临床试验中，用于治疗抑郁症，精神分裂症和注意缺陷多动障碍（ADHD）。
靶点信息
| 5-HT1A | human noradrenergic α1B | Dopamine D2L | 5-HT2A receptors | α2C receptors |
| 0.12 nM(Ki) | 0.17 nM(Ki) | 0.3 nM(Ki) | 0.47 nM(Ki) | 0.59 nM(Ki) |
化学数据
| 目录号 | A13527 |
| 作用机制 | Agonist (激动剂) |
| M. Wt | 433.5733 |
| Formula | C25H27N3O2S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 913611-97-9 |
| Synonyms | OPC 34712, OPC-34712 |
| SMILES | C1CN(CCN1CCCCOC2=CC3=C(C=C2)C=CC(=O)N3)C4=C5C=CSC5=CC=C4 |
溶解度
| In vitro | DMSO | 21 mg/mL (48.43 mM) |
| Water | Insoluble |
| Ethanol | Insoluble |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 23.06 mL | 115.32 mL | 230.64 mL |
| 0.5 mM | 4.61 mL | 23.06 mL | 46.13 mL |
| 1 mM | 2.31 mL | 11.53 mL | 23.06 mL |
| 5 mM | 0.46 mL | 2.31 mL | 4.61 mL |
*The above data is based on the productmolecular weight 433.5733. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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