Description: Sancycline HCl (GS-2147; Bonomycin; NSC51812), the hydrochloride salt of Sancycline, is a semi-synthetic tetracycline antibiotic that acts by binding reversibly to the 30S ribosomal subunit and inhibiting protein translation by blocking entry of aminoacyl-tRNA into the ribosome A site. It was first reported in 1962 and is more active than tetracycline against 339 strains of anaerobic bacteria (average MIC90s = 1 and 32 μg/ml, respectively). As the simplest of the early tetracyclines, sancycline was the first to be totally synthesised by Conover and co-workers. Like other tetracyclines, sancycline acts by reversibly binding to the 30S ribosomal subunit and inhibiting protein translation by blocking entry of aminoacyl-tRNA into the ribosome A site.

References: Int J Pharm. 2013 Jun 25;450(1-2):225-34.

Related CAS#: 6625-20-3 (free base); 6625-20-3 (HCl)

纯度：≥98%

CAS：6625-20-3