| CAS NO: | 26328-04-1 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 25mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| 250mg | 电议 |
| 500mg | 电议 |
| 1g | 电议 |
| 2g | 电议 |
| Molecular Weight (MW) | 533.57 |
|---|---|
| Formula | C22H31N3O5.C4H4O4 |
| CAS No. | 26328-04-1 |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO: 107 mg/mL (200.5 mM) |
| Water: 107 mg/mL (200.5 mM) | |
| Ethanol: <1 mg/mL | |
| Other info | Chemical Name:
1-[(1-Pyrrolidinylcarbonyl)methyl]-4-(3,4,5-trimethoxycinnamoyl)piperazine Maleate InChi Key: XSTJTOKYCAJVMJ-GVTSEVKNSA-N InChi Code: InChI=1S/C22H31N3O5.C4H4O4/c1-28-18-14-17(15-19(29-2)22(18)30-3)6-7-20(26)25-12-10-23(11-13-25)16-21(27)24-8-4-5-9-24;5-3(6)1-2-4(7)8/h6-7,14-15H,4-5,8-13,16H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b7-6+;2-1- SMILES Code: O=C(N1CCN(CC(N2CCCC2)=O)CC1)/C=C/C3=CC(OC)=C(OC)C(OC)=C3.O=C(O)/C=C\C(O)=O |
| Synonyms | NSC-291562; Cinepazide maleate; Cinepazide; MD 67350; NSC 291562; NSC291562; MD-67350; MD67350; Brendil; Vasodistal |
| In Vitro | In vitro activity: Cinepazide maleate is a maleate salt form of cinepazide which is a vasodilator. Cinepazide (30 mg/kg, i.v.) potentiated the vertebral vasodilator response of dogs to intravertebral adenosine and cyclic AMP |
|---|---|
| In Vivo | Cinepazide (3 mg/kg -30 mg/kg, i.v.) produces a dose-related and transient increase in vertebral, carotid, renal and femoral arterial flow as well as cardiac output and a decrease in total peripheral resistance in anesthetized dogs. Cinepazide exerts positive inotropic and chronotropic actions. Cinepazide (30 mg/kg, i.v.) potentiates the vertebral vasodilator response of dogs to intravertebral adenosine and cyclic AMP. Intravertebral cinepazide (1 mg -10 mg) increases vertebral blood flow in a dose-related manner and the effect is partially inhibited by intravenous pretreatment with aminophylline but not by pretreatment with autonomic antagonists. Cinepazide is well absorbed and more than 60% of the dose is excreted within 24 hours. In 5 days, rats, dogs, and man excretes in the urine and faeces respectively 36.7% and 58.3%, 33.4% and 68.6%, and 61.3% and 38.1% dose. Cinepazide at doses of 1 mg/kg - 3 mg/kg i.v. decreases systemic blood pressure by 4% and reflexly increases heart rate by 8%. Cinepazide selectively stimulates the functional activities of 5-HT neurons in the brain, which are depressed by hypoxia. |
| Animal model | Male Wistar rats |
| Formulation & Dosage | Dissolved in saline; 4 mg/kg, 20 mg/kg, 100 mg/kg and 150 mg/kg; i.p. injection |
| References | Nihon Yakurigaku Zasshi. 1979 Jul;75(5):507-16; Jpn J Pharmacol. 1986 May;41(1):109-15. |
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