Description: 740 Y-P HCl, the hydrochloride salt form of 740Y-P, is a novel, potent and cell-permeable peptide-based activator of PI3K. 740 Y-P plays an important role in PI3K/AKT signaling pathway. When tested with human melanoma MNT-1 cells, 20 μM 740 Y-P for 24 hours treatment significantly reduced the number of M6PR-positive vacuoles induced by sucrose via activating PI3K. In cerebellar granule cells in the circumstance of serum deprivation, 740 Y-P treatments reduced the cell death rate via binding to p85 which was correlated with PI 3-kinase-dependent phosphorylation of Akt process.

References:Mol Cell Neurosci. 1999 Apr;13(4):272-80; Biochem Biophys Res Commun. 1998 Oct 9;251(1):148-52.

纯度：≥98%