| CAS NO: | 54527-84-3 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 1g | 电议 |
| 2g | 电议 |
| 5g | 电议 |
| 10g | 电议 |
| Molecular Weight (MW) | 515.99 |
|---|---|
| Formula | C26H29N3O6.HCl |
| CAS No. | 54527-84-3 (HCl); |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO: 100 mg/mL (193.8 mM) |
| Water: <1 mg/mL | |
| Ethanol: <1 mg/mL | |
| Other info | Chemical Name: 2-(Benzylmethylamino)ethyl methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylatemonohydrochloride InChi Key: AIKVCUNQWYTVTO-UHFFFAOYSA-N InChi Code: InChI=1S/C26H29N3O6.ClH/c1-17-22(25(30)34-4)24(20-11-8-12-21(15-20)29(32)33)23(18(2)27-17)26(31)35-14-13-28(3)16-19-9-6-5-7-10-19;/h5-12,15,24,27H,13-14,16H2,1-4H3;1H SMILES Code: CC1=C(C(C(=C(N1)C)C(=O)OCCN(C)Cc2ccccc2)c3cccc(c3)[N+](=O)[O-])C(=O)OC.Cl |
| Synonyms | Nicardipine HCl; YC 93; YC93; Cardene, RS69216; Nicardipine Hydrochloride; RS-69216; RS 69216; YC-93; Antagonil, Dagan, Flusemide |
| In Vitro | In vitro activity: Nicardipine HCl (also known as YC-93 HCL, and trade names: Cardene, Antagonil, Dagan, Flusemide) is a dihydropyridine calcium-channel blocking agent used for the treatment of vascular disorders such as high blood pressure, angina, chronic stable angina and Raynaud's phenomenon. Nicardipine hydrochloride is the hydrochloride salt form of Nicardipine and a potent L-type calcium channel protein inhibitor. It is described to alter cytochrome P-450 3A expression through induction of CYP3A. Nicardipine blockade of Ca2+ channels has been correlated to antihypertensive effects. |
|---|---|
| In Vivo | |
| Animal model | |
| Formulation & Dosage | |
| References | Invest Ophthalmol Vis Sci. 1992 Sep;33(10):2885-90; J Hypertens Suppl. 1996 Oct;14(3):S29-35. |
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