吲哚美辛是一种非选择性COX抑制剂(人COX-1和COX-2的IC50s = 1.67和24.6μM)。
中文别名 | 53-86-1;茚甲新;消炎痛;吲哚美辛;非选择性COX抑制剂 |
英文别名 | Indomethacin;Non-selective COX inhibitor;Lausit;Catlep;Tannex;Bonidin; Indometacin; Indacin; Amuno; Inacid;MFCD00057095;EINECS 200-186-5;Dolovin |
CAS号 | 53-86-1 |
SMILES | CN1CCN2c3c(cccn3)Cc4ccccc4C2C1 |
Inchi | InChI=1S/C17H19N3/c1-19-9-10-20-16(12-19)15-7-3-2-5-13(15)11-14-6-4-8-18-17(14)20/h2-8,16H,9-12H2,1H3 |
InchiKey | RONZAEMNMFQXRA-UHFFFAOYSA-N |
分子式 Formula | C19H16ClNO4 |
分子量 Molecular Weight | 357.79 |
闪点 FP | 215.3±28.7 ℃ |
熔点 Melting point | 158-162℃ |
沸点 Boiling point | 1300℃ |
Polarizability极化度 | 32.0±0.5 10-24cm3 |
密度 Density | 2.9000 |
溶解度Solubility | Soluble in acetone (40 mg/mL - clear, yellow solution), ethanol (20 mg/mL), ether, castor oil; Soluble in chloroform (50 mg/mL - clear, yellow, extremely viscous solution); decomposed by strong alkali but stable in neutral or slightly acidic media; insolu |
储藏条件 Storage conditions | Store at 4℃,-4℃下存储更优 |