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K-252a(SF 2370)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
K-252a(SF 2370)图片
CAS NO:99533-80-9
规格:≥98%
包装与价格:
包装价格(元)
50mg电议
100mg电议
250mg电议

产品介绍

K-252a (SF-2370) is a naturally occuring staurosporine analog and an alkaloid extracted from Nocardiopisis bacteria, with IC50 values of 470 nM, 140 nM, 270 nM, and 1.7 nM for PKC, PKA, Ca2+/calmodulin-dependent kinase type II, and phosphorylase kinase, respectively. K-252a is a potent inhibitor (IC50 of 3 nM) of the tyrosine protein kinase (TRK) activity of the NGF receptor gp140trk, the product of the trk protooncogene. This staurosporine analogue is a highly potent cell permeable inhibitor of CaM kinase and phosphorylase kinase (IC50 = 1.8 and 1.7 nmol/L, respectively). At higher concentrations it is also an efficient inhibitor of serine/threonine protein kinases (IC50 of 10 to 30 nmol/L).

纯度:≥98%

CAS:99533-80-9