CAS NO: | 326914-06-1 |
规格: | ≥98% |
包装 | 价格(元) |
1mg | 电议 |
2mg | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
1g | 电议 |
Molecular Weight (MW) | 387.39 |
Formula | C17H21N7O4 |
CAS No. | 326914-06-1 |
Storage | -20℃ for 3 years in powder form |
-80℃ for 2 years in solvent | |
Solubility (In vitro) | DMSO: 33 mg/mL (85.2 mM) |
Water: <1 mg/mL | |
Ethanol: <1 mg/mL | |
Other info | Chemical Name: 4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine InChi Key: MSSXBKQZZINCRI-UHFFFAOYSA-N InChi Code: InChI=1S/C17H21N7O4/c25-24(26)14-3-1-13(2-4-14)18-15-19-16(22-5-9-27-10-6-22)21-17(20-15)23-7-11-28-12-8-23/h1-4H,5-12H2,(H,18,19,20,21) SMILES Code: O=[N+](C1=CC=C(NC2=NC(N3CCOCC3)=NC(N4CCOCC4)=N2)C=C1)[O-] |
Synonyms | MHY-1485; MHY 1485; MHY1485 |
In Vitro | In Vitro activity: MHY1485 suppresses the basal autophagic flux. MHY1485 causes the accumulation of LC3II and enlargement of the autophagosomes in a dose- and time- dependent manner. MHY1485 increases phospho-mTOR levels and phosphorylation of downstream S6K1 and rpS6 proteins without affecting total mTOR content, total S6K1 and rpS6 levels. Short-term treatment of ovaries with MHY1485 followed by allo-transplantation promoted secondary follicle growth. Treatment with MHY1485 and subsequent grafting allowed the derivation of mature oocytes and healthy offspring.
Cell Assay: MHY1485 (10 μM; 4 hours) shows that GCDC-induced autophagic activity is s inhibited by upregulating p-mTOR expression and downregulating LC3 and p62 expression in HCC cells. MHY1485 (5 μM; 6 hours) increases the LC3II/LC3I ratio in a dose and time-dependently manner due to presumably inhibited LC3II degradation in rat liver Ac2F cells. MHY1485 (0.5-2 μM; 6 hours) increases the phosphorylation of mTOR at ser2448 and upregulates the level of phosphorylation of 4E-BP1 in a dose-dependently manner in Ac2F cells. |
In Vivo | N/A |
Animal model | N/A |
Formulation & Dosage | N/A |
References | PLoS One. 2012;7(8):e43418; PLoS One. 2015; 10(2): e0117769. |