生物活性
Rolapitant，也称为SCH-619734，是一种选择性的，可生物利用的CNS渗透性神经激肽NK1受体拮抗剂，在呕吐动物模型中显示出行为效应。
化学数据
| 目录号 | A13680 |
| 作用机制 | Antagonist (拮抗剂) |
| M. Wt | 500.5 |
| Formula | C25H26F6N2O2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 552292-08-7 |
| Synonyms | SCH619734, SCH-619734, SCH 619734 |
| SMILES | C[C@H](C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)OC[C@]2(CC[C@]3(CCC(=O)N3)CN2)C4=CC=CC=C4 |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 19.98 mL | 99.9 mL | 199.8 mL |
| 0.5 mM | 4 mL | 19.98 mL | 39.96 mL |
| 1 mM | 2 mL | 9.99 mL | 19.98 mL |
| 5 mM | 0.4 mL | 2 mL | 4 mL |
*The above data is based on the productmolecular weight 500.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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