Irinotecan hydrochloride (also known as CPT-11; (+)-Irinotecan) is a potent topoisomerase I inhibitor for LoVo cells and HT-29 cells with IC50 of 15.8 μM and 5.17 μM, respectively. Irinotecan hydrochloride is the semisynthetic derivative of camptothecin, a cytotoxic, quinoline-based alkaloid extracted from the Asian tree Camptotheca acuminata. Irinotecan is a prodrug that has to be converted to a biologically active metabolite 7-ethyl-10-hydroxy-camptothecin (SN-38) by a carboxylesterase-converting enzyme. SN-38 is 1000-fold more potent than its parent compound irinotecan.

纯度：≥98%

CAS：100286-90-6