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SirReal2
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
SirReal2图片
CAS NO:709002-46-0
规格:≥98%
包装与价格:
包装价格(元)
25mg电议
50mg电议
100mg电议
250mg电议
500mg电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)420.55
FormulaC22H20N4OS2
CAS No.709002-46-0
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 84 mg/mL (199.7 mM)
Water: <1 mg/mL
Ethanol: <1 mg/mL
Other info

Chemical Name: 2-[(4,6-Dimethyl-2-pyrimidinyl)thio]-N-[5-(1-naphthalenylmethyl)-2-thiazolyl]acetamide

InChi Key: MENNDDDTIIZDDN-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H20N4OS2/c1-14-10-15(2)25-22(24-14)28-13-20(27)26-21-23-12-18(29-21)11-17-8-5-7-16-6-3-4-9-19(16)17/h3-10,12H,11,13H2,1-2H3,(H,23,26,27)

SMILES Code: O=C(NC1=NC=C(CC2=C3C=CC=CC3=CC=C2)S1)CSC4=NC(C)=CC(C)=N4

Synonyms

SirReal 2; SirReal-2; SirReal2

实验参考方法
In Vitro

In vitro activity: SirReal2 selectively inhibits Sirt2 via a Sirt2-specific amino acid network, and induces a tubulin hyperacetylation and a significant depletion of BubR1 in HeLa cells.


Kinase Assay: SirReal2 is a potent, isotype-selective Sirt2 inhibitor with an IC50 value of 140 nM and has very little effect on the activities of Sirt3-5. SirReal2 leads to tubulin hyperacetylation in HeLa cells and induces destabilization of the checkpoint protein BubR1

In VivoIn vivo, SirReal2 inhibits Sirt2 activity without affecting the activity of the other Class-I sirtuins Sirt1 and Sirt3.
Animal modelN/A
Formulation & DosageSirReal2 (12.5, 25, and 50 μM) treatment did not induce the increase in acetylation of p53
References

Nat Commun. 2015 Feb 12;6:6263