CL2A-SN-38, an SN-38 (topoisomerase-I inhibitor) analogue, is a peptide-based drug linker used to synthesize antibody drug conjugates (ADC). It is composed of a potent DNA Topoisomerase I inhibitor SN-38 and a linker CL2A, which provides significant and specific anticancer effects against a panel of human solid tumors. CL2A-SN-38 is conjugated to the anti-Trop-2-humanized antibody, SN-38-anti-Trop-2 antibody-drug conjugate (ADC) against several human solid tumor types, provides significant and specific antitumor effects against a range of human solid tumor types.

纯度：≥98%

CAS：1279680-68-0 (free base)