CAS NO: | 127516-23-8 |
规格: | ≥98% |
包装 | 价格(元) |
2mg | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
Doxercalciferol Impurity is a major impurity of doxercalciferol, which is a synthetic analog of vitamin D2 and a potent activator of Vitamin D receptor with important biological activities. It suppresses parathyroid synthesis and secretion, and has been used to treat secondary hyperparathyroidism and metabolic bone disease. Doxercalciferol (100 or 300 pg/g b.w.) normalizes serum calcium and parathyroid hormone (PTH) levels in nephrectomy treated mice. Doxercalciferol (300 pg/g b.w.) significantly reduces osteitis fibrosa in nephrectomy treated mice. Doxercalciferol results in significant decrease in cardiac hypertrophy and improves cardiac function in rats fed a high salt (HS) diet. Doxercalciferol treatment leads to a significant decrease in plasma brain natriuretic peptide (BNP) level and tissue atrial natriuretic factor (ANF) mRNA level in rats fed a high salt (HS) diet.
纯度:≥98%
CAS:127516-23-8