CCT241533 is a novel, potent and selective CHK2 inhibitor with an IC50 of 3 nM
and a Ki of 1.16 nM. It shows >63-fold selectivity for Chk1 over
Chk2 and a panel of 84 other kinases. CCT 241533 dihydrochloride
inhibits Chk2 activation in response to etoposide-induced DNA damage in
HT29 cells and blocks ionizing radiation-induced apoptosis of mouse
thymocytes.