Suramin, a polysulfonated naphthylurea analog, is a novel and potent DNA topoisomerase II inhibitor with an IC50 of 5 μM. It has demonstrated various biological activities, for example, Suramin sodium is used as an antiparasitic drug. The mechanism of action for suramin is unclear, however, it is thought that parasites are able to selectively uptake suramin via receptor-mediated endocytosis of drug that is bound to low-density lipoproteins and to a lesser extent, other serum proteins. Once inside parasites, suramin combines with proteins, especially trypanosomal glycolytic enzymes to inhibit energy metabolism.

纯度：≥98%

CAS：145-63-1