This product is discontinued due to commercial reason. Rac-Nedisertib (Rac-M3814) is a racemate of Nedisertib. Nedisertib (M-3814, MSC-2490484A) is a poten, selective and orally bioavailable inhibitor of DNA-dependent protein kinase (DNA-PK) with an IC₅₀ of<3 nM and with potential antineoplastic and chemo/radiosensitizing activities. Upon oral administration, the DNA-PK inhibitor MSC2490484A binds to and inhibits the activity of DNA-PK. This inhibits the ability of tumor cells to repair damaged DNA, which may lead to a reduction in cellular proliferation of cancer cells expressing DNA-PK.

纯度：≥98%

CAS：1637542-34-7