Description: (5Z,2E)-CU-3 is a novel, potent and selective diacylglycerol kinase alpha (DGKalpha) inhibitor with an IC50 value of 0.6 μM, attenuating cancer cell proliferation and simultaneously enhancing immune responses including anti-cancer immunity. CU-3 competitively inhibits the affinity of DGKα for ATP with a Km value of 0.48 mM. (5Z,2E)-CU-3 targets the catalytic region, but not the regulatory region of DGKα. (5Z,2E)-CU-3 has antitumoral and proimmunogenic effects, enhances the apoptosis of cancer cells.

References: A novel diacylglycerol kinase α-selective inhibitor, CU-3, induces cancer cell apoptosis and enhances immune response. J Lipid Res. 2016 Mar;57(3):368-79.; Dirac and Nodal Line Magnons in Three-Dimensional Antiferromagnets. Phys Rev Lett. 2017 Dec 15;119(24):247202. doi: 10.1103/PhysRevLett.119.247202. Epub 2017 Dec 13. PubMed PMID: 29286729.

纯度：≥98%

CAS：1815598-71-0