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TAS4464
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
TAS4464图片
CAS NO:1848959-10-3
规格:≥98%
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍

Description: TAS4464 (hydrochloride) is a novel, highly potent and selective inhibitor of NEDD8 activating enzyme (NAE), with an IC50 of 0.955 nM, showing superior antitumor activity with prolonged target inhibition. TAS4464 selectively inhibited NAE relative to the other E1s UAE and SAE. TAS4464 showed prolonged target inhibition in human tumor xenograft mouse models; weekly or twice a week TAS4464 administration led to prominent antitumor activity in multiple human tumor xenograft mouse models including both hematologic and solid tumors without marked weight loss. It is a promising agent for the treatment of a variety of tumors including both hematologic and solid tumors.

References: TAS4464, a highly potent and selective inhibitor of NEDD8 activating enzyme, suppresses neddylation and shows antitumor activity in diverse cancer models. Mol Cancer Ther. 2019 May 15.

Related CAS#: 1848959-11-4 (HCl); 1848959-10-3 (free base)

纯度:≥98%

CAS:1848959-10-3