CAY10471 (rotation +) (also known as TM-30089) is a novel, potent and highly selective prostaglandin D2 receptor CRTH2 antagonist with a Ki of 0.6 nM for hCRTH2, it is selective over human thromboxane A2 receptor TP (Ki, >10000 nM) or PGD2 receptor DP (Ki, 1200 nM). CAY10471 Racemate also has effect on mouse and rat orthologs of CRTH2. CAY10471 Racemate (Compound 13) inhibits PGD2-induced inositol phosphate or cAMP formation, suppresses β-arrestin translocation with IC50s of 12 and 3 nM, respectivel

纯度：≥98%

CAS：627865-18-3