您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > BNC105P
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
BNC105P
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
BNC105P图片
CAS NO:945771-96-0
规格:≥98%
包装与价格:
包装价格(元)
50mg电议
100mg电议
250mg电议

产品介绍

BNC105P, the disodium phosphate ester of BNC105, is a potent benzofuran-based tubulin polymerization inhibitor and also a vascular disrupting agent (VDA) prodrug with potential anti-vascular and anticancer activities. BNC105P is rapidly converted to BNC105 under in vivo conditions. BNC105 binds to tubulin and inhibits its polymerization, which may result in a blockage of mitotic spindle formation, cell cycle arrest, and disruption of the tumor vasculature. Hypoxic conditions ensue, depriving tumor cells of nutrients and resulting in tumor cell apoptosis. In addition to its VDA activity, this agent has a direct cytotoxic effect on tumor cells by inhibiting tubulin polymerization. BNC105 is not a substrate for the multidrug-resistance P-glycoprotein (Pgp) transporter.

纯度:≥98%

CAS:945771-96-0