Tenofovir
hydrate (formerly also known as GS-1278; PMPA; TDF) is an approved anti-HIV
drug that blocks reverse transcriptase and hepatitis B virus infections.
Tenofovir is an antiretroviral medication used to prevent and treat
HIV/AIDS and to treat chronic hepatitis B. Tenofovir reduces the viral
cytopathic effect of HIV-1(IIIB), HIV-2(ROD) and HIV(EHO) with EC50 of
1.15 μg/mL, 1.12 μg/mL and 1.05 μg/mL in MT-4 cells. Tenofovir also
reduces the viral cytopathic effect of SIV(mac251) , SIV(B670)
,SHIV(89.6) and SHIV(RTSHIV). Tenofovir is the active substance of
tenofovir disoproxil which is a prodrug that is used because of its
better absorption in the gut.