Radicicol (Monorden), an antifungal antibiotic with antimalarial activity, is a potent Hsp90 N-terminal inhibitor with an IC50 value of 1 μM. It binds to the ATPase domain of Hsp90 and prevents maturation of Hsp90 clients, leading to proteasomal degradation. Radicicol impairs mitochondrial replication by targeting P. falciparum topoisomerase VIB.

纯度：≥98%

CAS：12772-57-5