Dooku1, an analog of Yoda1, is a novel, potent and selective antagonist of the endogenous Piezo1 channel. Dooku1 inhibited 2 μM Yoda1-induced Ca2+-entry with IC50 of 1.3 μM (in HEK 293 cells) and 1.5 μM (in HUVECs). Dooku1 inhibits Yoda1-induced relaxation of aorta. Yoda 1 is a novel and potent agonist of Piezo1 which is the mechanotransduction channel. Yoda 1 activates purified Piezo1 channels. Yoda1 works by eliciting Ca2+ flux in Piezo1- but not vector-transfected cells.

纯度：≥98%

CAS：2253744-54-4