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Halobetasol Propionate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Halobetasol Propionate图片
CAS NO:66852-54-8
规格:≥98%
包装与价格:
包装价格(元)
50mg电议
100mg电议
250mg电议
500mg电议
1g电议
2g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)484.96
FormulaC25H31ClF2O5
CAS No.66852-54-8
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 97 mg/mL (200.0 mM)
Water: <1 mg/mL
Ethanol: 38 mg/mL (78.4 mM)
SMILESC[C@@]12[C@](C(CCl)=O)(OC(CC)=O)[C@@H](C)C[C@@]1([H])[C@]3([H])C[C@H](F)C4=CC(C=C[C@]4(C)[C@@]3(F)[C@@H](O)C2)=O
SynonymsHalobetasol Propionate; BMY30056, CGP14458; BMY 30056, CGP 14458; BMY-30056; CGP-14458; Ulobetasol propionate
实验参考方法
In Vitro

In vitro activity: Halobetasol propionate is thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2. The initial interaction, however, is due to the drug binding to the cytosolic glucocorticoid receptor. After binding the receptor the newly formed receptor-ligand complex translocates itself into the cell nucleus, where it binds to many glucocorticoid response elements (GRE) in the promoter region of the target genes. The DNA bound receptor then interacts with basic transcription factors, causing the increase in expression of specific target genes.

In Vivo
Animal model
Formulation & Dosage
References

Indian J Dermatol Venereol Leprol. 2009 Mar-Apr;75(2):186-7; Am J Clin Dermatol. 2005;6(5):311-6.