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PF-06447475
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PF-06447475图片
CAS NO:1527473-33-1

产品介绍

PF06447475 is a highly potent, selective, brain penetrant, and in vivo active LRRK2 kinase inhibitor. Leucine rich repeat kinase 2 (LRRK2) has been genetically linked to Parkinson's disease (PD) by genome-wide association studies (GWAS). The most common LRRK2 mutation, G2019S, which is relatively rare in the total population, gives rise to increased kinase activity. As such, LRRK2 kinase inhibitors are potentially useful in the treatment of PD.
中文别名PF-06447475(MSDS,1527473-33-1); PF06447475; PF-06447475; PF 06447475; PF6447475; PF-6447475; PF 6447475.
英文别名PF-06447475;PF-06447475:
CAS号1527473-33-1
SMILESc1cc(cc(c1)c2c[nH]c3c2c(ncn3)N4CCOCC4)C#N
InchiInChI=1S/C17H15N5O/c18-9-12-2-1-3-13(8-12)14-10-19-16-15(14)17(21-11-20-16)22-4-6-23-7-5-22/h1-3,8,10-11H,4-7H2,(H,19,20,21)
InchiKeyBHTWDJBVZQBRKP-UHFFFAOYSA-N
分子式 FormulaC17H15N5O
分子量 Molecular Weight305.33
Polarizability极化度33.8±0.5 10-24cm3
密度 Density1.4±0.1 g/cm3
储藏条件 Storage conditions粉末Powder: -20℃ 3 years年 4℃ 2 years年 / In solvent溶液中:-80℃ 6 months月 -20℃ 1 month月