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Pipendoxifene hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Pipendoxifene hydrochloride图片
CAS NO:245124-69-0
规格:≥98%
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
500g电议

产品介绍

Description: Pipendoxifene HCl (ERA923 hydrochloride) is an estrogen antagonist (SERM) with antitumor activity. It inhibits estrogen binding to ER-alpha with IC50 of 14 nM. In ER-alpha-positive human MCF-7 breast carcinoma cells, ERA-923 inhibits estrogen-stimulated growth (IC50 = 0.2 nM) associated with cytostasis. In vitro, a MCF-7 variant with inherent resistance to tamoxifen (10-fold) or 4-OH tamoxifen (>1000-fold) retains complete sensitivity to ERA-923 . In preclinical models, ERA-923 has an improved efficacy and safety compared with tamoxifen. In the combination with temsirolimus, ERA-923 showed excellent anticancer activity in preclinical models.

References: Endocr Relat Cancer. 2006 Sep;13(3):863-73.


纯度:≥98%

CAS:245124-69-0