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Sulfameter
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Sulfameter图片
CAS NO:651-06-9
规格:≥98%
包装与价格:
包装价格(元)
500mg电议
1g电议
5g电议
10g电议
25g电议
50g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)280.3
FormulaC11H12N4O3S
CAS No.651-06-9
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 56 mg/mL (199.8 mM)
Water: <1 mg/mL
Ethanol: <1 mg/mL
Other info

Chemical Name: 4-amino-N-(5-methoxypyrimidin-2-yl)benzenesulfonamide

InChi Key: GPTONYMQFTZPKC-UHFFFAOYSA-N

InChi Code: InChI=1S/C11H12N4O3S/c1-18-9-6-13-11(14-7-9)15-19(16,17)10-4-2-8(12)3-5-10/h2-7H,12H2,1H3,(H,13,14,15)

SMILES Code: O=S(C1=CC=C(N)C=C1)(NC2=NC=C(OC)C=N2)=O

Synonyms

NSC-683528; Sulfameter; I-2586; I 2586; NSC683528; I2586; SH 613; Sulfametoxipirimidine; Solfametossidiazina [DCIT]; NSC 683528;

实验参考方法
In Vitro

In vitro activity: Sulfameter(Bayrena) is a long-acting sulfonamide antibacterial. It is used as a leprostatic agent in the treatment of urinary tract infections. Six physically healthy patients each were given 2 g of sulfameter simultaneously with a high lipid, high protein and high carbohydrate test meal. This experiment was designed as a threefold crossover study, and there was a randomized assignment of patients to the different conditions. The results show that sulfameter is significantly better absorbed when administered with a high lipid meal than when given with a high protein or high carbohydrate meal, demonstrated by the areas under the serum concentration curves (AUC), by the peak serum concentration and by the cumulative renal excretion.

In Vivo
Animal model
Formulation & Dosage
References

Int J Clin Pharmacol Biopharm. 1979 Jun;17(6):260-3; Clin Pharmacol Ther. 1969 Jul-Aug;10(4):591-4.