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Devimistat(CPI-613)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Devimistat(CPI-613)图片
CAS NO:95809-78-2
规格:≥98%
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
250mg电议
500mg电议
1g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)388.59
FormulaC22H28O2S2
CAS No.95809-78-2
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 78 mg/mL (200.7 mM)
Water: <1 mg/mL
Ethanol: 78 mg/mL (200.7 mM)
Solubility (In vivo)1% DMSO+30% polyethylene glycol+1% Tween 80: 30 mg/mL
SynonymsCPI613; CPI-613; Devimistat; CPI 613

Chemical Name: 6,8-bis(benzylthio)octanoic acid

SMILES Code: O=C(O)CCCCC(SCC1=CC=CC=C1)CCSCC2=CC=CC=C2

实验参考方法
In Vitro

In vitro activity:In vitro, CPI-613 produces the selective toxicity against several tumor cell lines including H460 human lung cancer cells and Saos-2 human sarcoma cells with EC50 of 120 μM and 120 μM, respectively. CPI-613 disrupts H460 cancer cell mitochondrial metabolism including inhibition of PDH complex activity and loss of mitochondrial membrane potential in a time- and drug dose-dependent fashion. In addition, CPI-613 (240 μM) also induces both apoptotic and non-apoptotic cell death in H460 human lung cancer and Saos-2 human sarcoma cells.


Cell Assay: Devimistat (CPI-613) is a lipoic acid analog that inhibits pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase, disrupts mitochondrial metabolism and shows strong antitumor activity.

In VivoCPI-613 (25 mg/kg) has potent anticancer activity in a human tumor xenograft model of of a pancreatic tumor cell (BxPC-3). Similarly, CPI-613 (10 mg/kg) also produces significant tumor growth inhibition of H460 human non-small cell lung carcinoma in mouse model. Besides, CPI-613 produces little or no side-effect toxicity in expected therapeutic dose ranges in large animal models and has the maximum tolerated dose of 100 mg/kg in mice.
Animal modelCD1 nu/nu mice bearing BxPC-3 and H460 cells tumor models
Formulation & DosageDissolved in DMSO and then diluted in water.; 25 mg/kg; i.p. administration
ReferencesJ Mol Med (Berl). 2011 Nov;89(11):1137-48.