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Tranylcypromine hemisulfate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Tranylcypromine hemisulfate图片
CAS NO:13492-01-8
规格:≥98%
包装与价格:
包装价格(元)
50mg电议
100mg电议
250mg电议
500mg电议
1g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)182.23
FormulaC9H12NO2S0.5
CAS No.13492-01-8
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 5 mg/mL
Water: 46.66 mg/mL
Ethanol:
Solubility (In vivo)
SynonymsTranylcypromine, Parnate, d-Tranylcypromine, Transamine
实验参考方法
In Vitro

In vitro activity: R-(+)-Tranylcypromine, (±)-Tranylcypromine, and S-(–)-Tranylcypromine competitively inhibits CYP2A6-mediated metabolism of nicotine with apparent Ki values of 0.05 μM, 0.08 μM, and 2.0 μM, respectively, in human liver microsomes. Tranylcypromine (500 μg/mL) severely inhibits bradykinin-stimulated arachidonic acid release in calf aortic endothelial cells. Tranylcypromine inhibits CYP2A6 and CYP2E1 activity with IC50 of 0.42 μM and 3 μM, respectively, in human liver microsomes. Tranylcypromine induces type II and cyclopropylbenzene type I difference spectrum in human liver microsomes.


Kinase Assay:


Cell Assay:

In VivoTranylcypromine injection leads to a large, slow increase in motor activity at 5 mg/kg and 10 mg/kg compared with the saline control in male rats, although 2 mg/kg Tranylcypromine does not induce an increase. Tranylcypromine (10 mg/kg) also causes significant decreases in the number of rearing behaviors in male rats.
Animal model
Formulation & Dosage
References

Drug Metab Dispos. 2001 Jun;29(6):897-902; Environ Health Perspect. 2004 Aug;112(11):1159-64.