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Isotretinoin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Isotretinoin图片
CAS NO:4759-48-2
规格:≥98%
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议
1g电议
2g电议
5g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)300.44
FormulaC20H28O2
CAS No.4759-48-2
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 60 mg/mL (199.7 mM)
Water: <1 mg/mL
Ethanol: 1 mg/mL (3.32 mM)
Other info

Chemical Name: (2Z,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid

InChi Key: SHGAZHPCJJPHSC-XFYACQKRSA-N

InChi Code: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14-

SMILES Code: CC(/C=C/C=C(/C=C/C1=C(CCCC(C)1C)C)C)=C/C(O)=O

Synonyms13-cis retinoic acid; Accutane; Isotretinoin; Myorisan; Zenatane
实验参考方法
In Vitro

In vitro activity: Isotretinoin directly interferes with the development of cranial neural crest cells. Isotretinoin selectively affects neural crest cells by decreasing their cell-substratum adhesion.

In VivoIsotretinoin (500 ng/mL) and its main metabolite in the human, 4-oxo-isotretinoin, induce malformations similar to those seen in vivo. Isotretinoin impairs explicit memory in Stage 2, but retention tests one month after Isotretinoin exposure ended, indicated recovery from this explicit memory impairment and evidence of enhanced implicit memory in the 10 mg and 15 mg ISO rats. Isotretinoin slows the recovery of rod signaling after exposure to an intense bleaching light, and that rhodopsin regeneration is markedly slowed. Isotretinoin is also found to protect rat photoreceptors from light-induced damage. Isotretinoin blocks the formation of A2E biochemically and the accumulation of lipofuscin pigments by electron microscopy. Isotretinoin also blocks the slower, age-dependent accumulation of lipofuscin in wild-type mice.
Animal modelMice
Formulation & Dosage
References

J Craniofac Genet Dev Biol. 1986;6(3):211-22; Dev Biol. 1987 Sep;123(1):276-81; Pharmacol Biochem Behav. 2008 Dec;91(2):243-51.