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(R)-Nepicastat HCl [RS-25560-198 HCl]
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
(R)-Nepicastat HCl [RS-25560-198 HCl]图片
CAS NO:195881-94-8
规格:≥98%
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
250mg电议
500mg电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)331.81
FormulaC14H15F2N3S.HCl
CAS No.195881-94-8
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 66 mg/mL (198.9 mM)
Water: <1 mg/mL
Ethanol: <1 mg/mL
Solubility (In vivo)30% propylene glycol, 5% Tween 80, 65% D5W: 30 mg/mL
SynonymsRS-25560-198 HCl; RS-25560 198 HCl; RS 25560-198 HCl; RS25560-198 HCl
SMILES CodeS=C1N([C@H]2CC3=C(C(F)=CC(F)=C3)CC2)C(CN)=CN1.[H]Cl
实验参考方法
In Vitro

In vitro activity: (R)-Nepicastat produces concentration-dependent inhibition of bovine and human dopamine-β-hydroxylase activity in vitro.

In Vivo(R)-Nepicastat (30 mg/kg, p.o.) reduces noradrenaline content, dopamine content and dopamine/noradrenaline ratio in mesenteric artery and left ventricle of spontaneously hypertensive rats (SHRs).
Animal modelAnimal Models Spontaneously hypertensive rats (SHRs).
Formulation & DosageDissolved in distilled water; 30 mg/kg; p.o.
References

Br J Pharmacol. 1997 Aug;121(8):1803-9.