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CH-223191
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CH-223191图片
CAS NO:301326-22-7
规格:≥98%
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
250mg电议
500mg电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)333.39
FormulaC19H19N5O
CAS No.301326-22-7
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 66 mg/mL (198.0 mM)
Water: <1 mg/mL
Ethanol: 4 mg/mL (12.0 mM)
SMILES CodeO=C(C1=CC=NN1C)NC2=CC=C(/N=N/C3=CC=CC=C3C)C=C2C
SynonymsCH223191; CH-223191; CH 223191.
实验参考方法
In Vitro

In vitro activity: CH-223191 blocks TCDD-mediated nuclear translocation and DNA binding of AhR, and also causes the inhibition of TCDD-induced cytochrome P450 enzyme activity. In human glioblastoma cells, CH-223191downregulates the TGF-beta/Smad pathway, and reduces clonogenic survival and invasiveness. In SK-N-SH human-derived neuronal cells, CH223191 counteracts the TCDD-induced suppression of neuronal acetylcholinesterase expression. In endothelial cells, CH-223191 potentiates ICAM-1 expression and prevents RelB nuclear translocation.

In VivoCH-223191 (10 mg/kg/day, p.o.) potently prevents TCDD-caused cytochrome P450 induction, liver toxicity, and wasting syndrome in mice.
Animal modelMale ICR mice
Formulation & DosageDissolved in Coin oil; 10 mg/kg; p.o.
References

Mol Pharmacol. 2006 Jun;69(6):1871-8; Oncogene. 2009 Jul 16;28(28):2593-605.