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UM729
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
UM729图片
CAS NO:1448723-60-1
规格:≥98%
包装与价格:
包装价格(元)
10mg电议
25mg电议
50mg电议
100mg电议
250mg电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)367.44
FormulaC20H25N5O2
CAS No.1448723-60-1
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 48 mg/mL (130.6 mM)
Water: <1 mg/mL
Ethanol: 9 mg/mL (24.5 mM)
SMILES Code O=C(OC)C1=CC=C(C2=C(NCCCN3CCCCC3)N=CN=C2N4)C4=C1
SynonymsC07 ;UM729, UM-729, UM 729
实验参考方法
In Vitro

In vitro activity: UM729 expands normal hematopoietic stem and progenitor cells (HSPCs) in an AhR-independent manner. UM729 prevents the AML cell differentiation. In cultured 05H163 cells, compared with AhR suppressors (flavonoid, benzothiophene, and β-carboline) alone, addition of UM729 improves the numbers of CD34+CD15- cells. UM729 has an additive effect with AhR antagonists in preventing differentiation in most AML specimens.


Cell Assay: CellTrace Violet is added at a final concentration of 3 μM to cell suspensions (107 cells/mL) containing SR1 (500 nM), UM729 (1 μM), both compounds or vehicle (0.1% DMSO). CellTrace Violet–labeled cells are stained with surface antibodies to human CD3, CD19, CD34 and CD33 on day 0, day 2 and day 4 before analysis on a flow cytometry.

In VivoIn NSG mice, UM729 increases engraftment but not leukemic stem cell (LSC) frequency when administered alone or in combination with SR1.
Animal modelFemale NSG mice
Formulation & DosageDissolved in DMSO; 1 μM; i.v.
References

Nat Methods. 2014 Apr;11(4):436-42.