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Trospium chloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Trospium chloride图片
CAS NO:10405-02-4
规格:≥98%
包装与价格:
包装价格(元)
25mg电议
50mg电议
100mg电议
250mg电议
500mg电议
1g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)427.96
FormulaC25H30NO3.Cl
CAS No.10405-02-4
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 41 mg/mL (95.8 mM)
Water: 86 mg/mL (201 mM)
Ethanol: 42 mg/mL (98.1 mM)
SMILES O=C(C(C1=CC=CC=C1)(O)C2=CC=CC=C2)O[C@@H]3C[C@H]([N+]45CCCC4)CC[C@H]5C3.[Cl-]
Synonyms IP631; Trospium chloride, IP-631; IP 631; trade name Sanctura; Tropez OD; Trosec; Regurin; Flotros; Spasmex; Spasmoly.
实验参考方法
In Vitro

In vitro activity: Trospium Chloride is a competitive muscarinic cholinergic receptor antagonist. Target: mAChR Trospium chloride is an antimuscarinic agent indicated for the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and urinary frequency.

In VivoTrospium has pharmacologic properties that are distinct from other antimuscarinic agents. After oral administration, absorption of the hydrophilic trospium chloride is slow and incomplete. Peak plasma concentrations (Cmax) of approximately 4 ng/mL are reached 4-5 hours after administration of a 20 mg immediate-release preparation. The mean bioavailability is approximately 10% and decreases by concomitant food intake (to a mean of 26% of the fasting area under the plasma concentration-time curve [AUC]). Trospium chloride displays dose proportional increases in AUC and Cmax after a single dose within the clinically relevant dose range (20-60 mg). The mean volume of distribution is approximately 350-800 L.
Animal model Mice PK model
Formulation & Dosage 20-60 mg
References Urol Clin North Am, 2006. 33(4): p. 465-73, viii.