Homatropine Bromide(Homatropine hydrobromide)

Molecular Weight (MW)	356.25
Formula	C16H21NO3.HBr
CAS No.	51-56-9
Storage	-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)	DMSO: 71 mg/mL (199.3 mM)
Water: 71 mg/mL (199.3 mM)
Ethanol: <1 mg/mL
Other info	O=C(C(C1=CC=CC=C1)O)O[C@H]2C[C@@H](CC3)N(C)[C@@H]3C2.Br
Synonyms	Homatropine hydrobromide; Equipin, Isopto Homatropine

Molecular Weight (MW)

356.25

Formula

C16H21NO3.HBr

CAS No.

51-56-9

Storage

-20℃ for 3 years in powder form

-80℃ for 2 years in solvent

Solubility (In vitro)

DMSO: 71 mg/mL (199.3 mM)

Water: 71 mg/mL (199.3 mM)

Ethanol: <1 mg/mL

Other info

O=C(C(C1=CC=CC=C1)O)O[C@H]2C[C@@H](CC3)N(C)[C@@H]3C2.Br

Synonyms

Homatropine hydrobromide; Equipin, Isopto Homatropine

In Vitro	In vitro activity: Homatropine (20 μM) alone produces a dose ratio of 259 in atrium from guinea-pigs. Homatropine (20 μM) produces a dose ratio of only 95.0 when combined with hexamethonium in atrium from guinea-pigs. Homatropine has similar affinities for muscarinic receptors in stomach (pA2 = 7.13) and for those in atria mediating force (pA2 = 7.21) and rate (pA2 = 7.07) responses.
In Vivo	Homatropine (20 mg/kg) prevents lethality in rats with dichlorvos poisoning with survive rate of 30% and time of death ranged between 4 and 12 minutes, while Homatropine (10 mg/kg) has no effect on preventing lethality. Homatropine [14C]methylbromide administrated rectal achieves higher and rapid peak plasma concentrations than by the other routes in rats whether HMB-14C is administered in a water-soluble suppository base or in aqueous solution, retained 28% of the 14C has been excreted in the urine while 56% remained in the large intestine after 12 hours. Unlabelled Homatropine methylbromide, given in rectal suppositories to anaesthetized rats, causes prompt blockade of the effects of vagal stimulation on pulse rate and of intravenous acetylcholine on blood pressure.
Animal model	Sprague-Dawley rats
Formulation & Dosage	Dissolved in saline; 20 mg/kg; Intramuscular injections
References	Eur J Pharmacol. 1982 May 7;80(1):11-7; J Med Toxicol. 2006 Dec;2(4):156-9.

In Vitro

In vitro activity: Homatropine (20 μM) alone produces a dose ratio of 259 in atrium from guinea-pigs. Homatropine (20 μM) produces a dose ratio of only 95.0 when combined with hexamethonium in atrium from guinea-pigs. Homatropine has similar affinities for muscarinic receptors in stomach (pA2 = 7.13) and for those in atria mediating force (pA2 = 7.21) and rate (pA2 = 7.07) responses.

In Vivo

Homatropine (20 mg/kg) prevents lethality in rats with dichlorvos poisoning with survive rate of 30% and time of death ranged between 4 and 12 minutes, while Homatropine (10 mg/kg) has no effect on preventing lethality. Homatropine [14C]methylbromide administrated rectal achieves higher and rapid peak plasma concentrations than by the other routes in rats whether HMB-14C is administered in a water-soluble suppository base or in aqueous solution, retained 28% of the 14C has been excreted in the urine while 56% remained in the large intestine after 12 hours. Unlabelled Homatropine methylbromide, given in rectal suppositories to anaesthetized rats, causes prompt blockade of the effects of vagal stimulation on pulse rate and of intravenous acetylcholine on blood pressure.

Animal model

Sprague-Dawley rats

Formulation & Dosage

Dissolved in saline; 20 mg/kg; Intramuscular injections

References

Eur J Pharmacol. 1982 May 7;80(1):11-7; J Med Toxicol. 2006 Dec;2(4):156-9.

CAS NO:	51-56-9
规格:	≥98%

包装	价格(元)
1g	电议
2g	电议
5g	电议
10g	电议
25g	电议