您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > Lefamulin acetate(BC-3781 acetate)
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Lefamulin acetate(BC-3781 acetate)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Lefamulin acetate(BC-3781 acetate)图片
CAS NO:1350636-82-6
规格:≥98%
包装与价格:
包装价格(元)
25mg电议
50mg电议
100mg电议
250mg电议
500mg电议
1g电议
5g电议

产品介绍

Lefamulin acetate (formerly BC3781; Xenleta), the acetate salt form of lefamulin, is a semi-synthetic, orally bioactive pleuromutilin antibiotic that acts as an inhibitor for the synthesis of bacterial protein. It is an approved medication for the treatment of community-acquired bacterial pneumonia. Lefamulin acts by binding to the peptidyl transferase center, or PTC, on the bacterial ribosome in such a way that it interferes with the interaction of protein production at two key sites known as the 'A' site and the 'P' site, resulting in the inhibition of bacterial proteins and the cessation of bacterial growth. Lefamulin's binding occurs with high affinity, high specificity and at molecular sites that are different than other antibiotic classes. Lefamulin exhibited MIC50 and MIC90 values of 0.12 and 0.25 μg/ml, respectively, against the entire collection (n = 822). Similar results were obtained for lefamulin against each of the most common serotypes as well as against multidrug-resistant isolates and strains that are nonsusceptible to ceftriaxone or erythromycin. Lefamulin may be useful for the treatment of community-acquired respiratory tract infections.

纯度:≥98%

CAS:1350636-82-6