您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > Hexamethonium Bromide
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Hexamethonium Bromide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Hexamethonium Bromide图片
CAS NO:55-97-0
规格:≥98%
包装与价格:
包装价格(元)
2g电议
5g电议
10g电议
25g电议
50g电议
100g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)362.19
FormulaC12H30N2.2Br
CAS No.55-97-0
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: <1 mg/mL
Water: 73 mg/mL (201.55 mM)
Ethanol: <1 mg/mL
Other infoChemical Name: N1,N1,N1,N6,N6,N6-hexamethylhexane-1,6-diaminium bromide

InChi Key: FAPSXSAPXXJTOU-UHFFFAOYSA-L

InChi Code: InChI=1S/C12H30N2.2BrH/c1-13(2,3)11-9-7-8-10-12-14(4,5)6;;/h7-12H2,1-6H3;2*1H/q+2;;/p-2

SMILES Code: C[N+](CCCCCC[N+](C)(C)C)(C)C.[Br-].[Br-]

SynonymsHexamethionium bromide; Vegolysen; Esametina; Simpatoblock;
实验参考方法
In Vitro

In vitro activity: Hexamethonium Bromide is effective against Ach and carbachol (CCh) on the amplitude of endplate responses of rat omohyoid muscle with EC50 of 300 μM and 100 μM, respectively. Hexamethonium Bromide (50-200 μM) causes an increase in the amplitude of nerve-evoked endplate currents (e.p.cs) recorded in the presence of 0.6 μM tubocurarine. Hexamethonium Bromide is also a weak inhibitor of acetylcholinesterase activity in rat muscle homogenates with EC50 of 1.5 mM. Hexamethonium Bromide (200 μM) decreases the time constant of decay of both endplate currents (e.p.cs) (by ~25%) and miniature endplate currents (m.e.p.cs) (by ~20%) in the rat hemi-diaphragm muscle. At low frequencies of stimulation (0.5-2 Hz), Hexamethonium Bromide (200 μM) increases e.p.c. quantal content by 30-40%.

In Vivo
Animal model
Formulation & Dosage
References

Br J Pharmacol. 1984 Mar;81(3):519-31; Br J Pharmacol. 1997 Nov;122(6):1025-34.