您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > Galanthamine HBr
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Galanthamine HBr
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Galanthamine HBr图片
CAS NO:1953-04-4
规格:≥98%
包装与价格:
包装价格(元)
50mg电议
100mg电议
250mg电议
500mg电议
1g电议
2g电议
5g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)368.27
FormulaC17H21NO3.HBr
CAS No.1953-04-4
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: <1 mg/mL
Water: 36 mg/mL (97.8 mM)
Ethanol: <1 mg/mL
Solubility (In vivo)Saline: 20 mg/mL
SynonymsGalantamine hydrobromide
实验参考方法
In Vitro

In vitro activity: Galanthamine has been demonstrated to have an IC50 of 14 nM and 15 nM on AChE in post-mortem human brain frontal cortex and the hippocampus region. Red-cell cholinesterase activity in blood samples from the neurosurgery patients is 10 times more strongly inhibited by Galanthamine in brain tissue samples. Galanthamine (1 μM) activates single channels with conductance's of 18 and 30 pS in outside-out patches excised from dexamethasone mouse fibroblasts (M10 cells). Galanthamine acts as noncompetitive nicotinic receptor agonists' on clonal rat pheochromocytoma (PC12) cells. Galanthamine (50 μM) activates single-channel currents in outside-out patches excised from clonal PC12 cells.

In VivoGalantamine significantly increases the number of living pyramidal neurons after ischemia-reperfusion injury. Galantamine significantly reduces TUNEL, active caspase-3, and SOD-2 immunoreactivity. The nicotinic antagonist mecamylamine blockes the protective effects of galantamine. The neuroprotective effects of galantamine are preserved even when first administered at 3 hours postischemia.
Animal modelGerbils
Formulation & DosageDissolved in 0.9% NaCl saline solution; 10 mg/kg; s.c. injection
References

Eur J Clin Chem Clin Biochem. 1991 Aug;29(8):487-92; J Pharmacol Exp Ther. 2007 Aug;322(2):591-9.