Demeclocycline calcium (Detravis; Ledermycin), the calcium salt of demeclocycline, is a
protein translation inhibitor and calpain inhibitor of the tetracycline antibiotic class. It is a semisynthetic tetracycline antibiotic isolated from a strain of Streptomyces aureofaciens. Demeclocycline binds
to bacterial 30S ribosomal subunit and prevents binding of
aminoacyl-tRNA to the mRNA-ribosome complex, thereby inhibiting protein
synthesis. Demeclocycline also inhibits the effect of vasopressin on the
renal tubules, thereby causing diuresis.
纯度:≥98%
CAS:17146-81-5