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NHI-2
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
NHI-2图片
CAS NO:1269802-97-2
规格:≥98%
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍

NHI-2 is a novel, potent, selective and cell membrane permeable inhibitor of human lactate dehydrogenase isoform A (LDH-A; IC50 values 14.7 μM and 55.8 μM in a NADH competition assay for LDH-A and LDH-B, respectively), whcih is a key enzyme necessary to sustain glycolysis, the major pathway used by many cancer cells for cell growth and proliferation (the Warburg effect). It acts by reducing lactate production in HeLa cells and has anti-glycolytic activity against a variety of cancer cells. NHI-2 inhibited cell growth of pancreatic cancer LPC006 and PANC-1 cells and enhanced the antiproliferative effects of Gemcitabine and caused apoptosis in colon cancer HCT116 cells.

纯度:≥98%

CAS:1269802-97-2