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Vidarabine(Ara-A)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Vidarabine(Ara-A)图片
CAS NO:5536-17-4
规格:≥98%
包装与价格:
包装价格(元)
500mg电议
1g电议
2g电议
5g电议
10g电议
25g电议
50g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)267.24
FormulaC10H13N5O4
CAS No.5536-17-4 (free);
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 53 mg/mL (198.3 mM)
Water: 3 mg/mL (11.2 mM)
Ethanol: <1 mg/mL
Other info

Chemical Name: (2R,3S,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol

InChi Key: OIRDTQYFTABQOQ-UHTZMRCNSA-N

InChi Code: InChI=1S/C10H13N5O4/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(18)6(17)4(1-16)19-10/h2-4,6-7,10,16-18H,1H2,(H2,11,12,13)/t4-,6-,7+,10-/m1/s1

SMILES Code: O[C@@H]1[C@H](N2C=NC3=C(N)N=CN=C23)O[C@H](CO)[C@H]1O

Synonyms

Adenine Arabinoside; 9-β-D-Arabinofuranosyladenine; Vira A; Vira-A; ViraA; Ara-A; Ara A; Arabinofuranosyladenine; 9-beta-Arabinofuranosyladenine; Vidarabine.

实验参考方法
In Vitro

In vitro activity: Vidarabine and Acyclovir have a synergistic effect on wild type . Vidarabine is capable of inhibiting acyclovir-resistant/TK-deficient mutants of HSV and VZV, because it is phosphorylated to its active vidarabine–triphosphate form by cellular kinases and is not dependent for its activation on the viral TK. Vidarabine and acyclovir (ACV) alone show a concentration-dependent inhibition of plaque formation of HSV-1 in Vero cells. Vidarabine combined with acidic protein bound polysaccharide (APBP) show synergistic effects on the plaque formation of HSV-1 in Vero cells. Vidarabine acts directly on the DNA polymerase of varicella-zoster virus (VZV) and double-strand DNA viruses, including human adenoviruses. Vidarabine specifically inhibits adenovirus type 11 replication without obvious cytotoxicity in vitro. Vidarabine acts less on the synthesis of early proteins but rather on those after DNA replication. Vidarabine is an antiviral drug with activity against herpes viruses, poxviruses, and certain rhabdoviruses, hepadnarviruses, and RNA tumor viruses. Vidarabine also is active against vaccinia virus both in vitro and in vivo.

In VivoVidarabine is rapidly deaminated to 9-β-D-arabinofuranosyl hypoxanthine (Ara-Hx) as the principal metabolite.
Animal model
Formulation & Dosage
References

Antiviral Res. 2006 Nov;72(2):157-61; Antivir Chem Chemother. 2004 Sep;15(5):281-5.